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Defining the relationship between early markers of atherosclerosis and the level of total cardiovascular risk (CVR) in a cohort of men.
Materials and methods
The study included 200 men aged 40-55 years with different levels of CVR without clinical manifestations of CVD. The total CVR was defined by the SCORE. Patients were divided into three groups: low and moderate risk <5%, the highest risk 10.5% and very high risk > 10%.
State of the intima-media thickness of the carotid arteries and peripheral arteries were determined by duplex scanning (Toshiba Nemio XG, Japan). Diagnostic criteria for peripheral atherosclerosis is ankle brachial index <0.90. Quantitative assessment of coronary calcium was determined using multislice computed tomography (Siemens, Germany).
In patients with low CVR thickening of the intima-media (>1 mm) was found in 58.3% of cases, patients with a high CVR in 57.7% of cases, whereas the pathology of the carotid artery was diagnosed in all patients with a very high CVR. The increase in CVR associated with an increase in the frequency of dysfunction of the peripheral arteries. For example, if a group of low-and moderate-risk ankle-brachial index <0.9 was found in 16.6% of patients, those with high CVR, its frequency increases twice and is 38.4%. In the group of patients with very high CVR every second identified early markers of peripheral atherosclerosis. In the group of low-moderate and high CVR is moderate calcium index (11-100) was observed with the same frequency: 16.6% and 15.4%, respectively. In a group of very high risk, every third patient has moderate calcium index. A high coronary risk was not detected in more than one group, with the exception of high CVR (in 3.8% of cases).
Thus, the increase in total CVR associated with increasing thickness of the intima-media and frequency of peripheral atherosclerosis. A similar pattern is detected by a moderate degree of coronary index.