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Purpose. Patients and Methods
To evaluate correlation of angiographic peculiarities and NT-proBNP plasma levels in coronary heart disease (CHD) pts with various left ventricular myocardium mass indices (LVMMI) 232 men 40-60 years old with stable angina were investigated. The 1st study group included 117 pts whose LVMMI had been within normal range (<125 g/m2; M ±m - 114,1±1,8 g/m2), the 2nd study group included 115 patients with left ventricular hypertrophy (LVH; LVMMI>125 g/m2; M ±m -162,1±4,6 g/m2, p <0,005). CHD duration had been 3,3±0,5 and 3,7±0,6 years correspondingly. 68 (58,1%) pts 1st group and 55 (50,9%) patients 2nd group had previously survived myocardial infarction. In addition to clinical, laboratory and instrumental examinations, a coronarography and determinations NT-proBNP plasma levels had been carried out.
The 2nd group pts compared with 1st group pts demonstrated significantly higher plasma NT-proBNP concentrations (9,9±1,2 pg/mL vs 5,4 ±1,7pg/mL, correspondingly; normal range 0 - 200 pg/mL). Total cholesterol, LDL, HDL and triglycerides plasma levels were not differed significantly between both groups pts. Intact coronary arteries had been found more frequently in 1st group pts (10,3%), than in patients with LVH (1,7%). Coronary arteries hemodynamic lesions had been found both in 1st (81,1%) and 2nd (95,9%) group pts. In 1st group one affected coronary artery had been found in 58 (49,5%) pts, two affected arteries in 16 (13,6 %) and more than two affected coronary arteries in 8 (6,8%) pts. In 2nd group more than two affected coronary arteries had been found in 77 (66,9%), two affected arteries in 22 (19,1%) and one affected coronary artery only in 13 (11,3%) pts. Affected left main stem coronary artery (LMS) had been found in 18 (15,6%) pts with LVH, while intact LMS had been revealed in all pts with normal LVMMI. Also, other affected main coronary arteries such as anterior interventricular artery, diagonal artery, left circumflex artery, obtuse marginal artery, and right coronary artery had been found more frequently in LVH pts.
Our data revealed a close relationship between plasma NT-proBNP concentration and increased myocardial mass index, therefore NT-proBNP may be used as informative criterion in assessment of morphologic and functional status of a heart. Clinically significant hemodynamic lesions of three and more coronary arteries as well as affected main coronary arteries had been found more frequently (with statistical validity) in LVH patients.