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Several studies have established the important role of CRP in the development of coronary collateral circulation. The correlation between neutrophil/lymphocyte (N/L) ratio and collateral formation in patients with stable coronary artery disease (CAD) has not been reported.
We investigated the association between N/L ratio and the development of coronary collaterals in a cohort of 152 patients who had high-grade coronary stenosis or occlusion on their angiograms. To classify coronary collateral circulation, we used the Rentrop classification.
Patients with poorly developed coronary collateral circulation had significantly higher N/L ratio compared with those with well-developed coronary collateral circulation, (4.2±4.1 vs. 3.1±2.6, p=0.039), whereas mean platelet volume (MPV), red blood cell distribution width (RDW) and uric acid were not significantly different. Logistic regression analysis showed that N/L ratio was an independent predictor of poorly developed coronary collateral circulation (odds ratio 0.752, 95% confidence interval 0.593–0.993).
An elevated level of N/L ratio is independently associated with a significant impairment in coronary collateralization; patients with poorly developed collaterals tend to have a higher N/L ratio.