Author + information
- Sinan Cerşit1,
- Serkan Çay1,
- Yavuzer Koza2,
- Sadık Kadri Açıkgöz1,
- Gizem Çabuk1,
- Bihter Şentürk1 and
- Pınar Doğan1
Fibrinogen is related to pathogenesis of atherosclerosis. The inflammatory process in atherosclerosis may cause an increase in plasma fibrinogen level. Therefore, in this study we purposed to investigate whether plasma fibrinogen is associated with the patency of saphenous vein graft in patients at least 1 year after coronary artery bypass graft (CABG) surgery.
Patients who had undergone CABG surgery at least 1 year previously with at least one saphenous vein graft were included in the study. Patients were directed to cardiac catheterization for stable anginal symptoms or positive stress test results. Before coronary angiography, all patients had routine blood tests including plasma fibrinogen levels.
Saphenous vein grafts were found to be patent in 199 patients and occluded in 132 patients. Plasma fibrinogen levels were significantly different between the two groups (2.85±0.49 g/L vs. 3.62±0.82 g/L, p<0.001, respectively). Although time after CABG operation differs significantly between the two groups (p=0.004), multiple logistic regression analysis showed that plasma fibrinogen levels were found to be significantly associated with the patency of vein graft (OR=0.27, 95% CI 0.16-0.48, p<0.001) (Table). In addition, a plasma fibrinogen value >3.45 g/L was determined to predict saphenous graft vein disease with a sensitivity of 57% and a specificity of 91% (AUC (area under the curve) =0.784) (Figure).
Our results demonstrated that plasma fibrinogen levels were higher in patients with an occluded saphenous vein graft. To prove this relationship between plasma fibrinogen values and saphenous vein graft patency, further investigations are needed.
|Odds ratio||95% confidence interval||P value|
|Time after CABG surgery||0.93||0.87-0.99||0.04|
CABG, coronary artery bypass graft; HDL, high-density lipoprotein; MPV, mean platelet volume.