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Aspirin is an inhibitor of platelet function and is one of the cornerstones of acute coronary syndrome (ACS) treatment. However, the ideal dose and usage of aspirin in patients with ACS is not clear. The aim of this study is to investigate the antiplatelet effects of different aspirin doses and application ways in patients with ACS.
This study included 30 patients that were admitted to Cardiology Clinic of Ankara University Faculty of Medicine with a diagnosis of acute coronary syndrome. The patients included in the study were divided into three groups based on the dose of aspirin utilization (1x100 mg, 1x300 mg, and 3x100 mg). On 3rd day of acute coronary syndrome, thrombocyte aggregation levels, which were assesed by VerifyNow® aspirin test, were compared at 2 hours (early) and 24 hours (late) after initial aspirin.
Ten of the patients (33%) were women and 20 were men (67%) and mean age was 61.2±11.5 years. According to demographic and laboratory characteristics, no statistical difference was determined between the groups. Antiplatelet effect of aspirin at 2nd hour were as follows respectively; 402.4±29.3 ARU in aspirin 300mg per day group, 440.4±36.7 ARU in 100mg 3 times a day group and 418.2±41 ARU in aspirin 100 mg per day group (p=0.04). All groups’ ARU values were increased at 24th hour compared with first 2nd hour measurements but this increase was minimum in 3x100 mg aspirin group. There were no difference in ARU values at 24th hour measurement between groups. No aspirin resistance observed in any of the patients.
Antiplatelet effect of both 100 mg and 300 mg aspirin doses decreased during the day but their efficacy still continued and no difference was detected between the doses. Despite the theoretical advantages of the use of aspirin in divided doses, our study did not support this.
Key Words: aspirin, aspirin resistance, acute coronary syndrome, platelet function.
|Grup I (n=10)|
|Grup II (n=10)|
|Grup III (n=10)|
|2nd hour VerifyNow ARU||402,4±29,3||440,4±36,7||418,2±41||0,04|
|24th hour VerifyNow ARU||432,3±29||453,9±45,7||452,4±45,2||0,45|