Author + information
- Durmuş Yıldıray Şahin,
- Mustafa Gür,
- Zafer Elbasan,
- Nermin Yıldız Koyunsever,
- Caner Türkoğlu,
- Selahattin Akyol,
- Arafat Yıldırım,
- Gökhan Gözübüyük,
- Betül Özaltun and
- Murat Çaylı
The high N-terminal pro-brain natriuretic peptide (NT-proBNP) level provides significant prognostic information in patients with coronary artery disease (CAD). It is unclear whether aortic distensibility (AD) which reflects aortic stiffness and extent and complexity of CAD assessed with SYNTAX score (SS) affects the secretion of NT-proBNP in stable CAD. We aimed to investigate the relation between NT-proBNP levels with AD and extent and complexity of CAD in stable CAD.
The study included 411 patients with stable CAD (Mean age=61.7±9.9 years, male/female= 247/164). The patients were divided into two groups according to the median NT-proBNP value (NT-proBNPlow group < 114 pg/ml and NT-proBNPhigh group ≥114 pg/ml). Aortic distensibility was calculated from the echocardiographically derived ascending aorta diameters and hemodynamic pressure measurements. Coronary angiography was performed and SS were determined in all patients. NT-proBNP and other biochemical markers were measured in all subjects.
Aortic distensibility and ejection fraction values of NT-proBNPhigh group were lower and their SS levels were higher compared with NT-proBNPlow group (p<0.05, for all) (Table). NT-proBNP level was independently associated with AD (β=-0.378, p<0.001), SS (β=0.262, p<0.001) and ejection fraction (β=-0.295, p<0.001) on multiple linear regression analysis.
NT-proBNP was independently associated with impaired elastic property of aorta and extent and complexity of CAD, as well as left ventricle systolic dysfunction.
|Variables||NT-proBNPlow Group (n=205)||NT-proBNPhigh Group (n=206)||p|
|Ejection Fraction (%)||65.6±4.3||62.4±4.3||<0.001|
|Aortic Distensibility (cm2 dyn-1 x10-6)||3.2±1.5||1.7±0.77||<0.001|