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The increased incidence of CAD in men compared with premenopausal women suggests a detrimental role of male hormones on the cardiovascular system. From a large study performed at the University Hospital Center of Tirana, who has study the correlation of testosterone levels with CAD. We have analyzed correlation in the group of young men.
This study was planned to determine the relationship between serum testosterone levels and premature development of coronary artery disease in men.
225 men under age 50 who performs coronarygraphy 143 men with documented coronary artery disease (mean age 44.06±4.2) constituted the study group. Control group consisted of 82 men with similar age and coronary angiography normal (mean age 42.13±4.6). Within this group we have analyzed the correlation in the youngest group: 32 men until 40 years of age (mean age 37.3±3.01) with documented CAD. Control group consisted of 29 men with similar age (mean age 36.8±2.7) and normal coronary angiography:Levels of testosterone, low-density lipoprotein, and high-density lipoprotein cholesterol, and triglyceride levels were measured, and compared between the two groups.
Mean age, body mass index, the frequency of hypertension, and family history of coronary artery disease was similar between the two groups; however, diabetes mellitus, smoking, were more frequent in the (CAD) coronary artery disease group p=0.001. Low levels of HDL-c, high level of triglyceride, were more frequent in the CAD group p<0.05. The testosterone levels of the patients with coronary artery disease were (5.2±1.8 nnmol/ml) significantly lower than those of controls (7.6±2.4 nmol/ml) p<0.000. This difference is visible in the younger group: The testosterone levels of the patients with CAD were (5.14±1.7 nmol/ml) significantly lower than those of controls 7.2±2.33nmol/ml p<0.000. The multivariate logistic regression analysis of all risk factors for CAD in the patients of our study, revealed that besides diabetes mellitus (p=0,002), HBP (p=0,0048), smoking (p=0,31), BMI (p=0,029), low free testosterone level (p=0,000; odds ratio=0,57; 95% confidence interval = 0,52 – 0,63) was an independent risk factor for CAD.
A low level of testosterone related to the development of premature coronary artery disease in men. A low level of testosterone result as an independent risk factor for CAD.