Author + information
- Murtaza Emre Durakoğlugil1,
- Aytun Çanga2,
- Sinan Altan Kocaman2,
- Remzi Adnan Akdoğan3,
- Tuğba Durakoğlugil4,
- Elif Ergül2,
- Halil Rakıcı3,
- Gökhan İlhan5 and
- Mehmet Bostan1
Irritable bowel syndrome (IBS), a subgroup of functional somatic disorders, may be associated with autonomic dysfunction (AD). Heart rate variability (HRV), a measure of autonomic dysfunction, may predict survival. The aim of this study was to investigate the effect of IBS on HRV parameters, carotid intima-media thickness (CIMT) and carotid-femoral pulse wave velocity (cf-PWV) as surrogates of AD, subclinical atherosclerosis and arterial stiffness, respectively.
Thirty consecutive patients with IBS and 30 control participants underwent 24-hour Holter monitoring, cf-PWV assessment and CIMT measurement. The diagnosis of IBS was based on Rome III criteria. There were 24 patients with IBS-Constipation (80%), 4 patients with IBS-Diarrhea (13.3%), and 2 patients with IBS-Mixed (6.7%) in IBS group.
Biochemical parameters did not differ between groups except for slightly increased creatinine in patients with IBS. PWV and CIMT values were similar between groups. SDNN index and RMSSD were significantly impaired in patients with IBS compared to controls. Frequency analyses revealed lower LF, HF, and VLF in subjects with IBS.
We demonstrated decreased parasympathetic modulation in patients with constipation predominant IBS. However, we could not demonstrate any changes in vascular structure and functions measured by carotid intima-media thickness and pulse wave velocity. Our results do not support accelerated atherosclerosis in IBS population
|N (60)||IBS group (30)||Control group (30)||P value|
|Time domain HR variability|
|SDNN index, ms||51±12||62±18||0.010|
|Frequency domain HR variability|
|CIMT, mean (mm)||0.64±0.16||0.70±0.23||NS|
HRV, heart rate variability; RMSDD, Square root of the mean squared differences of successive normal-to-normal intervals; SDNN, Standard deviation of all normal-to-normal intervals; SDANN, standard deviation of the average normal-to-normal intervals calculated over 5-minute periods of the entire recording; HF, high frequency power; LF, low frequency power; LFnu, normalized low frequency power; HFnu, normalized high frequency power;CF-PWV, carotid-femoral pulse wave velocity; CIMT, Carotid intima-media thickness