Author + information
- Esra Gucuk Ipek1,
- Senay Akin Suljevic2,
- Habibe Kafes5,
- Funda Basyigit3,
- Neslihan Karalok4,
- Yesim Guray5,
- Lale Dinc Asarcikli5 and
- Haydar Demirel2
Galectin-3 is a new biomarker assumed to reflect fibrogenesis and inflammation. In this study, we aimed to evaluate the levels of galectin-3 in patients with acute coronary syndrome and the relation of galectin-3 with the severity of the coronary artery disease.
Nineteen patients with acute coronary syndrome who underwent coronary angiography and 17 age-matched controls without a history of coronary artery disease or heart failure were enrolled to the study. The burden of atherosclerosis was assessed by the number of involved vessels and the Gensini score. Serum samples were obtained to evaluate galectin-3 levels and ELISA test was used to measure galectin-3 levels. Continuous variables were expressed as mean ± standard deviation or median (interquartile range).
The mean age of the patients was 62.8±10.6 and 56% of the patients were male. Of all patients, 14% had diabetes, 31% had hypertension, 42% had hyperlipidemia, and 33% were active smokers. In the acute coronary syndrome group, 63% of the patients had non ST elevation myocardial infarction and 37% had ST elevation myocardial infarction. Compared to control group, the median galectin-3 levels were significantly higher in acute coronary syndrome patients [0.77 ng/ml (0.50-1.19) vs. 0.51 ng/ml (0.41-0.78), p=0.01]. When patients were classified into three groups according to their number of involved vessels, median galectin-3 levels did not differ significantly among groups [One vessel: 0.68 ng/ml (0.55-0.74), two vessels: 0.67 ng/ml (0.46-1.84), three vessels 0.90 ng/ml (0.53-1.38), p=0.62]. There was a strong correlation between galectin-3 levels and Gensini score (r=0.625, p=0.004). Galectin-3 levels were also correlated with other parameters such as glomerular filtration rate (r= -0.409, p=0.01), left ventricular ejection fraction (r= -0.479, p=0.03), and white blood cell count (r=0.381, p=0.02).
In our study, levels of galectin-3 were elevated in patients with acute coronary syndrome and correlated with Gensini score.
|Total (n=36)||AKS (n=19)||Control (n=17)||p|
|Glc (mg/dl)||114.5 (101.7-131.5)||123 (112.4-177)||111 (96-116.5)||0.01|
|Galectin (ng/ml)||0.67 (0.46-0.84)||0.77 (0.50-1.19||0.51 (0.41-0.78)||0.01|
AKS (acute coronary syndrome), BMI (body mass index), DM (diabetes mellitus), GFR (glomerular filtration rate), GLC (glucose), HL(hyperlipidemia), HT (hypertension)