Author + information
- Durmuş Yıldıray Şahin,
- Mustafa Gür,
- Zafer Elbasan,
- Arafat Yıldırım,
- Rabia Eker Akıllı,
- Nermin Yıldız Koyunsever,
- Betül Özaltun,
- Gökhan Gözübüyük,
- Ali Kıvrak and
- Murat Çaylı
The patients with increased mean platelet volume (MPV) values had a higher risk of developing myocardial infarction and adverse cardiovascular events in stable coronary artery disease (CAD). In this study, we aimed to assess the effective factors on high MPV in patients with stable CAD.
In all, 411 consecutive patients (247 males and 164 females; mean age: 61.7±9.9 years) with angiographically proven CAD were included in the study. Two different groups were determined according to MPV values (MPVlow group <9.5 fL, and MPVhigh group ≥9.5 fL). Aortic distensibility was calculated from the echocardiographically derived ascending aorta diameters and hemodynamic pressure measurements. Extent and complexity of CAD was calculated by the SYNTAX score. MPV, high sensitive C-reactive protein (hsCRP) and other biochemical markers were measured with an automated chemistry analyzer.
SYNTAX score, hsCRP levels and frequencies of diabetes and hypertension were higher in MPVhigh group compared with MPVlow group (p<0.05, for all). Aortic distensibilite value and platelet count of patients with MPVhigh group were lower than patients with MPVlow group (p<0.05, for all). Multivariate linear regression analysis showed that MPV was independently related with diabetes (β=0.135, p=0.007), hsCRP (β=0.259, p<0.001), platelet count (β=-0.144, p<0.001) and AD (β=-0.425, p<0.001). Although MPV was associated with SYNTAX score in bivariate analysis, similar relationship was not observed multivariate analysis (β=-0.034, p=0.579).
High MPV value in patients with stable CAD is independently related with AD, as well as diabetes, hsCRP and platelet count.
|Variables||MPVlow Group (n=205)||MPVhigh Group (n=206)||P value|
|Diabetes mellitus (%)||45 (22.0%)||109 (52.9%)||<0.001|
|AD (10-6 dyn-1 cm2)||3.1±1.4||1.8±1.2||<0.001|