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We sought to determine the relationship between the severity of the coronary artery disease measured with the Gensini score and the hemoglobin A1c (HbA1c) levels in non-diabetic patients with stable angina pectoris.
A total of 93 patients undergoing coronary angiography were included in the study. Patients were divided into 3 groups by use of Gensini score (21 patients with normal coronary arteries, 26 patients with mild atherosclerosis and 46 patients with severe atherosclerotic lesions). The associations between severity of coronary artery disease and HbA1c levels were assessed using logistic regression analysis.
The blood glucose readings were observed to be comparable between the groups (p=0.097). While the HbA1c values were higher in severe atherosclerosis group compared with mild atherosclerosis and normal coronary arteries groups (6.7±1.5, 6.0±0.8 and 5.6±0.6%, respectively, p=0.002). The HbA1c values were observed to be correlated with the Gensini score (r=0.374, p<0.001). A cutoff value of 6.0% for HbA1c predicted severe atherosclerosis with a sensitivity and specificity of 54% and 74%, respectively. In the multivariate analysis, high levels of HbA1c were observed to be independent predictors of severe atherosclerosis (OR: 1.975; 95% CI: 1.101-3.542, p=0.022).
Increasing levels of HbA1c in non-diabetic patients with stable angina pectoris are associated with the severe atherosclerosis that may help to predict the increased risk for coronary artery disease.