Author + information
- Ali Rıza Gülcan1,
- Mustafa Serkan Karakaş2,
- Barış Akdemir3,
- Mustafa Uçar4,
- Refik Emre Altekin4 and
- Hüseyin Yılmaz4
Metabolic syndrome (MetS) is associated with increased cardiovascular morbidity and mortality. There is evidence of platelet activation in MetS. Mean platelet volume (MPV), a determinant of platelet activation, is a newly emerging risk factor for atherothrombosis. Therefore, we have investigated the possible association between subclinical atherosclerosis,e valuated by carotid intima-media thickness (CIMT) measurement and MPV in MetS patients.
74 patients with MetS were enrolled to the study. Patients were divided into 2 groups according to CIMT measurement: 35 patients with CIMT ≥1,0 mm were at group 1 and 39 patients with CIMT <1,0 mm were at group 2. MPV were measured using an automated blood cell counter.
Patients between ages 30 and 60 years with MetS diagnosis were included in this study. 31 patients (41.9%) were male and 43 patients (58.9%) were female. Patients were divided into 2 groups according to CIMT measurement: 35 patients with CIMT ≥1,0 mm were at group 1 and 39 patients with CIMT<1,0 mm were at group 2. There were difference only age and fasting blood glucose parameter among groups. In the multi-varians analysis, age and fasting blood glucose related in CIMT values were not statistically significant (p>0.05). Additionally, the common effect of age and fasting blood glucose variables on the CIMT values were not statistically significant (p=0.241). The MPV level was significantly higher in patients with CIMT ≥1,0 mm than in patients with CIMT <1,0 mm (8.2±0.7 vs. 7.8±0.6 fl; p=0.01) (Figure 1).
The risk of atherosclerosis could be shown with following the MPV values in MetS patients. Therefore, our results suggest that MPV is an important marker for early detecting the risk of atherosclerosis in patients with MetS. In our study, we showed that this risk could be determined with a simple blood count. Risk of atherosclerosis can be assessed by examining the values of MPV, without any additional blood tests or radiological examination.
CIMT ≥1,0 mm (mean ±sd)
CIMT<1,0 mm (mean ±sd)
|Number of patients (n)||35||39|
|Gender (F/M, n)||23/12||19/20||0.16|
|Waist circumference (cm)||102.1±9.7||104.2±10.6||0.38|
|Fasting glucose (mg/dl)||114.4±24.7|
Baseline characteristcs of patients (BMI: body mass index, HT: hypertension, DM: diabetes mellitus, SBP: systolic blood pressure, DBP: diastolic blood pressure, LDL: low-density lipoprotein, HDL: high-density lipoprotein, MPV: mean platelet volume