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Coronary artery disease is one of the leading causes of mortality worldwide. The diagonal ear lobe crease (ELC) has been recommended as a simple, noninvasive marker of cardiovascular diseases. Epicardial adipose tissue (EAT) thickness and carotid intima media thickness (CIMT) are closely related to cardiovascular disorders and atherosclerosis. There is no knowledge abaout the relation between EAT thickness, CIMT and diagonal ELC. The aim of our study is to evaluate the association between EAT thickness, CIMT and ELC.
Study population was selected from apparently healthy individuals who were refered to hospital for a standard checkup. Sixty five subjects with ELC and sixty five age-gender matched control subjects without ELC were enrolled into this study. All subjects’ EAT thickness and CIMT were measured ultrasonographically. Both groups are compared according to the EAT and CIMT.
Demographical, biochemical and clinical characteristics of ELC and normal group is given in table 1. Mean EAT thickness of ELC group was significantly higher than the control group (0,57±0,12 versus 035±0,05, respectively, p<0,0001) and also CIMT is significantly higher in ELC group than normal group. (0,85±0,16 versus 0,60±0,15, respectively, p<0,0001) (Table 2). Multivariate logistic regression analysis showed that presence of ELC was indepedently associated with CIMT and EAT thickness.
We have shown for the first time that a significant and independent association between presence of ELC and increased EAT thickness and CIMT in subjects free of clinical cardiovascular disease