Author + information
- Firdevs Ayşenur Ekizler,
- Bihter Senturk,
- Burak Acar,
- Ozcan Ozeke,
- Pinar Dogan,
- Osman Turak,
- Firat Ozcan,
- Serkan Topaloglu and
- Dursun Aras
Catheter ablation has been the most effective treatment for paroxysmal atrial fibrillation (PAF). However, the optimal time to proceed with catheter ablation during the disease course is not well defined.
To assess whether or not the delays in treatment will negatively influence outcomes.
A total of 88 consecutive patients who underwent their first cryoballoon catheter ablation of symptomatic, medication-refractory PAF were prospectively followed for recurrence and AF symptoms, and were categorized as with and without recurrence.
After 15±7 months of follow-up, there were 66 patients without recurrence (Group 1) and 22 patients with recurrence (Group 2). There were no significant differences in any of the preprocedural variables between the both groups, except for the BMI. The time between first diagnosis of PAF and cryoballoon ablation procedure was statistically higher in recurrence group compared to Group 1 (91.7±6.8 vs 42.1±29.5; P<0.001). A Cox regression multivariate analysis of the variables including the BMI demonstrated that the time between first diagnosis of PAF and cryoballoon ablation procedure was an independent predictor of AF recurrence after a single cryoballoon ablation procedure [OR: 1.03 (1.01-1.04); 95% CI, P< 0.001)].
This study demonstrated that the time between first diagnosis of atrial fibrillation and cryoballoon ablation procedure predicts AF recurrence after cryoballoon ablation in patients with PAF