Author + information
- Hakan Uçar,
- Mustafa Gür,
- Taner Şeker,
- Durmuş Yıldıray Şahin,
- Gökhan Gözübüyük,
- Caner Türkoğlu,
- Arafat Yıldırım,
- Onur Kaypaklı,
- Zafer Elbasan and
- Murat Çaylı
The strong relationships between severe renal dysfunction with coronary artery disease (CAD) and arterial stiffness are well known. However, the associations between the kidney function with SYNTAX Score and aortic distensibility (AD) were not investigated in patients with stable CAD with normal to mildly impaired renal function. We aimed to investigate the association between kidney function with SYNTAX score and AD.
In this study, 411 stable CAD patients in whom coronary angiography was performed were prospectively included (247 male, 164 female; mean age 58.6±12.4 years). GFR was estimated (eGFR) by the Modification of Diet in Renal Disease formula. Two different groups were determined according to median eGFR values (GFRlow group <100.6, and GRFhigh group ≥100.6). Coronary angiography was performed based on clinical indications. SS was determined in all patients. AD was calculated from the echocardiographically
Patients with GFRlow group were older, and have a history of hypertension and diabetes mellitus and high BMI. SS and AD values of GFRlow group were higher than GFRhigh group (p<0.001 for all). Multivariate regression analysis showed that eGFR was independently associated with diabetes (β;-0.206, p<0.001), hypertension (β;-0.093, p=0.026), SS (β;-0.445, p<0.001) and AD (β;-0.096, p=0.019).
Estimated GFR is independently associated with extent and complexity of CAD and AD as well as frequencies of diabetes and hypertension. Importantly, these results may explain, in part, the increase in cardiovascular risk in with slightly impaired renal function.
|Variables||GFRlowgroup (n = 205)||GFRhighgroup (n = 206)||P value|
|DM, n (%)||120 (58.5%)||34 (16.5%)||<0.001×|
|HT, n (%)||117 (57.1%)||78 (37.9%)||<0.001×|