Author + information
- Alparslan Kurtul,
- Mikail Yarlıoğlueş,
- Muhammed Karadeniz,
- Gökhan Ergün,
- Mustafa Duran,
- Adil Hakan Öcek and
- Sani Namık Murat
The strong relationship between increased neutrophile to lymphocyte ratio (NRL) and cardiovascular disease has been shown in many studies. In this study, we investigated whether serum NLR levels affect coronary collateral circulation in patients with stable coronary artery disease
The study population consisted of 101 patients who underwent coronary angiography with a suspicion of coronary artery disease. Blood samples were taken and NLR levels were analyzed for all patients. Rentrop collateral classification was performed. Patients were divided into two groups on the basis of Rentrop scores: group I consisted of 40 patients (31 male, 16 female) with grade 0-1 collateral development regarded as poor collateral group and group II consisted of 61 patients (29 male, 14 female) with grade 2-3 collateral development regarded as good collateral group.
Table 1 indicated that there were no statistically significant differences between the study groups with regard to demographic characteristics and baseline laboratory findings. Table 2 concluded that Group 1 had significantly higher NLR levels compared with Group 2 (6.5±1.9 vs. 5.2±1.4 mg/dl, p=0.001). Figure 1 showed that NLR levels were higher in patients with absence of coronary collateral compared with patients with presence of coronary collateral (4.0±1.7 vs. 2.6±1.5, p=0.001).
Serum NLR level on admission is associated with poor CCC development and may be a useful biomarker for stratification of risk in patients with stable coronary artery disease.
|Group I (n=40)||Group II (n=61)||P value|
|Smoking (n, %)||10(25)||21(34)||0.21|
|Total cholesterol (mg/dl)||198 ±40||195 ±37||0.88|
|LDL cholesterol (mg/dl)||120±30||125±35||0.48|
|HDL cholesterol (mg/dl)||41±8||40±9||0.75|
|Group I (n=40)||Group II (n=61)||P values|
|Neutrophils,(x1000/μl)||6.5± 1.9||5.2± 1.4||0.001|
|Neutrophil/lymphocyte ratio||4.1± 1.7||2.1± 0.9||0.001|