Author + information
- İbrahim Halil Bayrak1,
- Abdullah Nurdag1,
- Veli Polat1,
- Mustafa Polat1,
- Evin Bozcali2 and
- Osman Karakaya1
Coronary slow flow(CSF) is defined as delayed progression and clearence of injected contrast without any stenosis in coronary arteries. Microvascular dysfunction, endotel and vasomotor dysfunction and occlusive diseases may have a role in the pathophysiology. Prolidase is a cytosolic ectopeptidase which has important role in collagen turnover. Previous studies have demonstrated the relationship between serum prolidase activity(SPA) and coronary artery disease(CAD). In our study, we tried to show the relationship between SPA and coronary slow flow.
Totally 80 patients; 40 of them with coronary slow flow and 40 patients without coronary slow flow are included into the study. Coronary slow flow diagnosis is performed due to TIMI frame counts in coronary angioraphy. Prolidase activities of the study population measured via the ELISA method in fasting blood samples. In statistical analysis, we used independent samples T test, chi-square test and in correlation analysis spearman rho correlation test was used.
There were no statistically significant difference in demographic, clinical and laboratory properties in two groups, but serum prolidase activity was significantly lower in normal coronary flow patients compared to slow coronary flow patients (p<0,001).
According to the current literature, our study is the only one that demonstrated the relation between serum prolidase activity and coronary slow flow and increase in serum prolidase activity may have a role in coronary slow flow phenomenon