Author + information
- Zeynettin Kaya1,
- Seref Ulucan1,
- Hüseyin Katlandur1,
- Ahmet Keser1,
- Abdullah Tuncez3,
- Yusuf İzzettin Alihanoğlu4,
- Duran Efe5,
- Mehmet Kayrak2 and
- Mehmet Sıddık Ülgen1
Peri-aortic fat tissue is one of the visceral adipose deposits. Visceral adipose tissue is metabolically active and it is suggested that has proatherogenic effects induced by oxidative stress. Previous studies have shown that the relationship between peri-aortic adipose tissue and metabolic risk factors, coronary artery disease, and systemic inflammation. In this study, the association between peri-aortic adipose tissue and long-term incidence of major adverse cardiovascular events (MACE) was investigated.
372 men, 61 women, a total of 433 consecutive patients between the ages 40- 75 were enrolled to the retrospective cohort study. Peri-aortic fat volumes were measured by electrocardiogram-gated 64-multi-detector computed tomography. In terms of the long-term incidence of MACE the three-year follow-up results of patients were evaluated. Patients were divided into two groups (group 1 that MACE was detected and group 2 those followed without any problem) according to results.
MACE (4 death, 22 nonfatal myocardial infarction (7 patients with STEMI and 15 non-STEMI), 4 ischemic stroke, 9 new onset atrial fibrillation, 5 newly diagnosed heart failure development) was detected in 44 (10.2%) patients during follow-up. Demographic and clinical characteristics were similar in both groups. Peri-aortic fat volumes were found statistically significantly high in group 1 (35.4±26.1 vs. 24.1±14.9, p=0.000). A multiple logistic regression analysis showed that peri-aortic fat volume (hazard ratio: 1.03 (95%CI 1.01-1.05), p=0.001), glomerular filtration rate (hazard ratio: 0.98 (95%CI 0.96-0.99), p=0.028), and male gender (hazard ratio: 4.76 (95%CI 1.08-20.90), p=0.039) were independent predictors of development of MACE. ROC analysis demonstrated that peri-aortic fat volumes above 29.6 was predict to development of MACE at sensitivity of 45.45% and at specificity of 76.55% (AUC: 0.61 (95% CI 0.567 to 0.661) p=0.015). In addition, CRP failed to predict MACE.
Peri-aortic fat volume can predict the development of long-term MACE independent of other clinical variables.
|Hazard Ratio||95%CI for Hazard Ratio||P|
|Step 8||Peri-aortic fat||1.03||1.01-1.05||0.001|
Logistics regression analysis for independent predictors of long term major adverse cardiovascular events (GFR: Glomerular filtration rate) (R2:0.59, P=0.000)