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Recent studies found that Lipoprotein(a) [Lp (a)] levels were lower in patients with type 2 diabetes than the non-diabetics. Little is known about the genetic determinants for Lp(a) levels in diabetic patients, and it remains unclear whether elevated Lp(a) levels may causally affect cardiovascular disease risk in the diabetic patients. LPA encodes apolipoprotein(a), and rs10455872 polymorphism in the LPA locus is associated with Lp(a) levels and cardiovascular risk factors. In this study, therefore, we aimed to investigate the effects of the rs10455872 polymorphism in the LPA gene locus on Lp(a) levels and risk factors for type 2 diabetes in the Turkish population.
We examined one single-nucleotide polymorphism (SNP) in LPA gene in the Turkish Adult Risk Factor (TARF) Study DNA bank which has been established between 2004-2010 years. The sample was comprised of 2252 Turkish adults. Genotyping was performed by high throughput system, Real-Time PCR LC480 device. The association between biochemical, clinical parameters and the polymorphism have been analyzed using SPSS software. For continuous variables, ANOVA T-test was used, whereas X2 analysis was performed for categoricals.
In this study, the first one to examine the rs10455872 polymorphism of the LPA gene in the Turkish population. The distribution of the LPA rs10455872 polymorphism in this adult population was 97% (n=2185), 3% (n=66) and 0% (n=1) for the AA, AG and GG genotypes, respectively. The rs10455872 in LPA gene locus was most strongly associated with higher Lp(a) levels (p<0.0001) in Turkish adults. In contrast, the LPA rs10455872 AG genotype was correlated lower HOMA index and insulin levels in Turkish adults (p<0.01). However, no significant relationship was found for the LPA rs10455872 polymorphism with type 2 diabetes in men and women.
The LPA rs10455872 AG genotype appears to be a risk factor against coronary heart disease by increasing the Lp(a). In contrast, AG genotype of the LPA gene independently confers protectiveness for type 2 diabetes by decreasing the HOMA index and insulin levels in Turkish adults.