Author + information
- Habil Yücel1,
- Abdullah Doğan2,
- Yasin Türker3,
- Atilla İçli4,
- Salaheddin Akcay5,
- İbrahim Ersoy2,
- Bayram Ali Uysal2 and
- Recep Sütçü6
Slow coronary flow (SCF) is characterized by delay of opacification of coronary arteries in coronary angiography in the absence of any evident obstructive lesion. Its pathophysiological mechanisms are uncertain. Several hypotheses have been suggested for SCF, including a form of early phase of atherosclerosis, microvascular dysfunction, inflammation, imbalance between vasoconstrictor and vasodilatory factors, and platelet function disorder. Endothelial nitric oxide synthase (eNOS) gene T-786 C polymorphism have been reported to be associated with many vascular disease.
The aim of this study was to investigate the association between SCF and eNOS gene T-786 C polymorphism.
Forty patients with SCF and otherwise normal coronary arteries (mean age 52±9 years), 35 patients with coronary artery disease (CAD) (mean age 55±9 years) and 30 patients with normal coronary angiograms (mean age 51±8 years) were included in the study. TIMI frame count ≥40 frames for the left anterior descending artery was considered as SCF. T-786 C polymorphisms of the eNOS gene were analysed by polymerase chain reaction. Demographic characteristics and major risk factors for atherosclerosis were evaluated in the study groups. The severity of SCF and CAD was assessed based on the number of involved vessel.
There was no significant difference with respect to age and gender between groups. The percentage of smoking was higher in the CAD group than in the SCF and control groups. There was no statistical difference in genotype distribution among the groups. The genotype distribution in SCF group was as follows: TT genotype frequency was 25 (62,5%)k, TC genotype frequency was 12 (30%) and CC genotype frequency was 3 (7,5%). The genotype distribution in CAD group was as follows: TT genotype frequency was 16 (45,7%), TC genotype frequency was 16 (45,7%) and CC genotype frequency was 3 (8,5%). The genotype distribution in control group was as follows: TT genotype frequency was 17 (56,6%), TC genotype frequency was 10 (33,3%) and CC genotype frequency was 3 (10%). In the dominant and recessive models of statistical analysis, there was no statistically significant difference among groups.
Our findings show that there is no significant association between T-786 C polymorphism of eNOS gene and SCF in the present study.