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Lipoprotein(a) [Lp(a)] level is an established risk factor for coronary heart disease (CHD) and has been implicated in carotid artery disease. The relationship between genetic variation in the LPA gene region and CHD risk remains unknown. In this study, therefore, we aimed to investigate the effects of the rs10455872 polymorphism in the LPA gene locus on Lp(a) levels and risk factors for CHD in the Turkish population.
We examined one single-nucleotide polymorphism (SNP) in LPA gene in the Turkish Adult Risk Factor (TARF) Study DNA bank which has been established between 2004-2010 years. The sample was comprised of 2252 Turkish adults. Genotyping was performed by high throughput system, Real-Time PCR LC480 device. The association between biochemical, clinical parameters and the polymorphism have been analyzed using SPSS software. For continuous variables, ANOVA T-test was used, whereas X2 analysis was performed for categoricals.
The distribution of the LPA rs10455872 polymorphism in this adult population was 97% (n=2185), 3% (n=66) and 0% (n=1) for the AA, AG and GG genotypes, respectively. The G allele frequency was found to be 0.03. The rs10455872 in LPA gene locus was most strongly associated with higher Lp(a) levels (p<0.0001). In addition, the LPA rs10455872 AG genotype was correlated higher total cholesterol and LDL-C levels in Turkish adults (p<0.05).
The LPA rs10455872 AG genotype appears to be a risk factor against CHD by increasing the Lp(a), total cholesterol and LDL-C levels.