Author + information
- Neşe Dursunoğlu1,
- Dursun Dursunoğlu2,
- Ali İhsan Yıldız1,
- Burcu Uludağ2,
- Zahide Namlı1,
- Ahmet Sarıçopur2 and
- Esma Öztürk1
Chronic obstructive pulmonary disease (COPD) has many comorbidities such as coronary artery disease (CAD) and lung cancer.
We analysed that impact of COPD on intensity and severity of coronary lesions on the angiogram in the groups of patients with COPD according to the Global Initiative for Obstructive Lung Disease (GOLD) grades updated in 2011.
The study included 102 patients with diagnosed COPD and 80 randomly selected subjects without any pulmonary disease who underwent coronary angiography. According to the GOLD grade for COPD, patients were divided into 4 groups: A, B, C and D. The severity and extent of CAD were determined using Gensini score.
There were no significantly differences in age, body mass index, smoking, plasma lipid levels, frequency of hypertension and diabetes. The mean Gensini score in COPD (25.7±32.9) was significantly higher than controls (17.5±24.8, p=0.01). While Gensini score was the highest level in group D (64.9±34.9), it was the lowest level in group A (10.2±19.4, p=0.0001). COPD was independently predictive for Gensini score after a multivariate logistic regression analysis (odds ratio 1.625; 95% confidence interval 2.172–12.232; p=0.001).
Severity and intensity of coronary atherosclerosis increases in accordance with increases in the GOLD grades.