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The aim of the study
Identification and assessment of the risk of diabetes in patients with different risk of cardiovascular complications in cardiology practice.
Materials and methods
The study included 300 men aged 40 to 69 years with low-to-moderate (<5% on the scale of SCORE, n=100), high (5-10% on a scale of SCORE, n=101) and very high (>10% on the scale of SCORE, n=99), cardiovascular risk without clinical manifestations of CVD and diabetes. Questioning the patients was conducted by Russian version of a standard questionnaire ARIC (Atherosclerosis Risk in Communities). Predicted risk of developing T2DM in the next 10 years was determined by questionnaire FINDRISC. All patients underwent tool (BP measurement, calculation BMI, waist circumference) and laboratory (lipids, C reactive protein, uric acid, immunoreactive insulin, fasting glucose and 2 hours after taking 75 g of glucose) study.
In the studied cohort of men with different levels of cardiovascular risk by SCORE scale in 28% of cases, revealed a low risk of developing T2DM, with 32.3% of those found moderately-high risk, whereas about 40% of men at the time of examination of a very high risk of developing T2DM. Among men with high and very high risk of developing T2DM in 53.8% of cases are of a very high cardiovascular risk. The men in the low-to-moderate cardiovascular risk pre-diabetes is detected in 21% of cases in individuals at high cardiovascular risk in 40% of cases, while 62% of men with very high cardiovascular risk is diagnosed early disorders of carbohydrate metabolism. Predicted risk of diabetes has the highest correlation with the level of fasting and after load blood glucose, immunoreactive insulin, with the cardiovascular risk by SCORE, BP, total cholesterol, LDL cholesterol and triglycerides. Mild but significant correlation was found between the risk of developing diabetes and uric acid, C-reactive protein, HDL cholesterol, left ventricular hypertrophy.
Thus, the application of the scale FINDRISK significantly expands the capabilities of primary care physicians to identify at-risk of developing diabetes. In the future, conducting advanced diagnostics in the form of glucose tolerance test to determine the tactics of prevention and medical correction to slow down and prevent diabetes in men with high and high cardiovascular risk.