Author + information
- Murat Sunbul1,
- Tarik Kivrak1,
- Mustafa Oguz1,
- Salih Ozguven2,
- Serkan Gungor2,
- Fuat Dede2,
- Halil Turgut Turoglu2,
- Bedrettin Yildizeli3 and
- Bulent Mutlu1
Chronic thromboembolic pulmonary hypertension (CTEPH) is a progressive disease characterized by increased pulmonary vascular resistance resulting in pulmonary hypertension and right heart failure. Previous studies have shown that right ventricular fluoro-D-glucose positron emission tomography (RV FDG-PET) uptake (RV/LV ratio) was associated with pulmonary vascular resistance in patients with idiopathic pulmonary arterial hypertension (IPAH). Aim of the present study is to explore association of RV FDG-PET uptake with RV functions in patients with CTEPH.
We enrolled 35 consecutive patients with CTEPH. All patients underwent a transthoracic echocardiogram and FDG-PET for evaluation of cardiac functions. Patients were divided into two groups according to tricuspid annular plane systolic excursion (TAPSE) measurements.
Patients characteristics and clinical data are shown in table. While fifteen patients had higher TAPSE value (≥15), twenty patients had decreased TAPSE value (<15). Patients with higher TAPSE value had higher RVS, PVR, and FDG PET (RV/LV ratio) value (Table).
Higher PDG PET (RV/LV ratio) is associated with impaired RV functions in patients with CTEPH. PDG PET (RV/LV ratio) may be a non-invasive marker for detection of impaired RV functions.
|Patients with TAPSE ≥ 15 (n=15)||Patients with TAPSE < 15 (n=20)||p|
|Age (years)||59.3 ± 12.7||51.6 ± 12.8||0.099|
|LVEF (%)||64.3 ± 5.4||64.1 ± 7.1||0.894|
|sPAB (mmHg)||60.9 ± 25.2||71.2 ± 32.0||0.282|
|RVS (cm/s)||12.9 ± 2.0||9.7 ± 2.2||<0.001|
|PVR (mmHg)||8.9 ± 6.1||13.8 ± 5.2||0.038|
|RV/LV FDG PET||0.97 ± 0.45||1.47 ± 0.68||0.036|
sPAP: Systolic pulmonary artery pressure; RVS: Right ventricular systolic velocity; TAPSE: Tricuspid annular plane systolic excursion; PVR: Pulmonary vascular resistance; LVEF: Left ventricular ejection fraction; RV/LV FDG PET: Right ventricular fluoro-D-glucose positron emission tomography