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Abnormal left ventricle (LV) geometric patterns are associated with a greater risk of hypertensive vascular complications. Red cell distribution width (RDW) reflects adverse cardiovascular outcomes and higher inflammatory status. Although association between RDW and hypertension has been investigated, relation between abnormal LV geometric patterns and RDW was not studied previously. The aim of this study was to investigate the relationship between RDW and abnormal LV geometric patterns in untreated essential hypertension.
Measurements were obtained from 139 patients with untreated essential hypertension (Mean age= 51.3±16.3 years). Four different geometric patterns (NG; normal geometry, CR; concentric remodelling, EH; eccentric hypertrophy, CH; concentric hypertrophy) were determined according to the LV mass index (LVMI) and relative wall thickness (RWT). RDW, lipid parameters and other biochemical markers were measured in all patients.
The highest RDW values were determined in CH group compared with NG, CR and EH groups (p<0.05, for all). RDW values were similar among the NG, CR and EH groups (p<0.05, for all). RDW was associated with age, LVMI and LV geometry in bivariate analysis (p<0.05, for all). Age (beta= 0.309, p=0.001), LV geometry type (beta= 0.228, p=0.01) and RWT (beta= -0,278; p=0.25) were independent predictors of high RDW in multiple linear regression analysis. The highest RDW values were observed in the CH group.
The highest RDW values were observed in the CH group compared with other geometric patterns independently of age and anemia. RDW could be a predictor of end organ damage in untreated hypertensive patients.
|Variables||NG group (n=36)||CR group (n=35)||EH group (n=30)||CH group (n=38)||f||P value|
|RDW (%)||13,7±1.0||13,7±1.1||13,7±0.8||14,7±1.5 c||5,225||0,002|
|LV MASS (g)||139,6±29.1||159,9±36.6||206.4±29.1||218,2±44.5||36.611||<0.001|