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Hypertension is principal problem increasing nowadays and threatens community health by its complications. In healthy adults, blood pressure levels decrease nocturnally. ‘Dipper’ are the ones whose systolic blood pressure decrease >10% at night and ‘nondipper’ are the whose ones systolic blood pressure decrease <10% at night. In the nondippers group cardiovascular morbidity and mortality are increased.
Our aim in this study is to search for the effect of diurnal blood pressure on endothelial functions in essential hypertensive patients.
Our study comprised 30 dippers, 31 nondippers hypertensive patients and 25 healthy volunteers. Ambulatory blood pressure monitoring (ABPM) was hooked-up to hypertensive patients and they were grouped as dippers and nondippers. All individuals were measured by using flow mediated dilatation (FMD) from brachial artery by used to echocardiography.
The groups are similar in term of age, sex, body mass index, using cigarette and biochemical parameters. In nondipper group, the use of beta blocker is higher than dipper group (p=0.023) but, there is no difference between dipper and nondipper hypertensive groups in term of using antihypertensive drugs. FMD in the control group were higher than dipper hypertensive group and in dipper hypertensive group FMD is higher than nondipper hypertensive group (respectively p= 0.003, p=0.023).
In our study we found a relationship among nondipper hypertension and increased endothelial dysfunction. Also, dipper hypertension related to increased endothelial dysfunction. Nondipper hypertension known has more increased cardiovascular event and mortality risk. In this context, patients with hypertension should be followed with ABPM. Therefore nondipper hypertensive patients which have a higher risk can be identified. Thus, efforts for controlling blood pressure in nondipper hypertensive patients provide better risk modification.