Author + information
- Ahmet Soylu1,
- Hayrudin Alibaşiç1,
- Elif Yıldırım3,
- Aysun Toker2,
- Halil İbrahim Erdoğan1,
- Mehmet Akif Düzenli1 and
- Mehmet Tokaç1
Number of studies have been performed on the hypertensive patients, related to the level of circulating aldosteron which leads to the cardiac fibrosis, and which is associated to the atrial fibrillation. The aim of our research is to see if there is a relation beetwen atrial electromechanical conduction time (As an indicator of the amount of the circulating aldosteron) and urinary amount of aldosterone observed in 24 hours in normotensive people.
The study included both an office and ambulatory blood pressure (BP) which were monitored in normotensive people (office blood pressure (BP) <140/90mmHg, and the average 24-hour BP <130/80 mmHg) in individuals who did not use any drugs and who were less than 60 years of age. A total of 85 people (54 women, with an average age of 46.2 ± 9.1 years) were included. İndividuals with any chronic disease, people who are smoking or who have used the drugs continiously were excluded from the study. Electromechanical atrial conduction time and both intra-atrial and interatrial conduction delays were measured by using tissue Doppler imaging. A time from the beggining of the P wave, which was noticed by using tissue Doppler, until the time from the beggining of the late diastolic wave (A wave) which is obtained from the septal, the right ventricle and tricuspid annulus was measured. Electromechanical delay between the atrial represents the difference between lateral PA and the tricuspid PA. The differences between septal PA and tricuspid PA, and lateral PA and septal PA are defined as electromechanical delay of the right atrial and electromechanical delay of the left atrial, respectively. By continuing with the normal nutrition, urin was collected in the 24 hours as sample to measure the level of adolesteron, and, under the adequate conditions, at the end of the study, the level of adolesteron was measured from all the samples (with the diametra aldosteron kit).
Demographic data are shown in Table 1. The researches performed on normotensive people showed that there is a correlation between the 24-hour amount of aldosteron and atrial conduction time.
The results of our research related to the amount of circulating aldosteron (which has been identified by measuring 24-hour urinary aldosterone), showed that it can cause the atrial arrhythmias such as atrial fibrilation.
|Female, n (%)||54 (63.5)|
|LA diametre (mm)||32.8±3.1|
|24h SBP (mmHg)||120.1±7.3|
|24h DBP (mmHg)||72.4±4.4|
|Daytime SKB (mmHg)||124.8±9.1|
|Daytime DKB (mmHg)||75.5±4.8|
|Night time SKB (mmHg)||112.5±9.2|
|Night time DKB (mmHg)||66.4±5.5|
|Urinary aldosterone (mgr/day)||9.1 (6.5, 13.7)|
Body mass index (BMİ) Left ventricular ejection fraction (LVEF) Left atrium (LA) systolic blood pressure (SBP) Dystolic blood pressure (DBP)
|tricuspid PA (ms)||Septal PA (ms)||Lateral PA (ms)||Septal PA-tricuspid PA (right ventricular conduction delay)||Laterl PA-Septal PA (left ventricular conduction delay)||Lateral PA- tricuspid PA (conduction delay between the atria)|
|Urinary aldosterone (mgr/day)||0.2 (0.069)||0.21 (0.050)||0.31 (0.004)||0.18 (0.099)||0.25 (0.019)||0.32 (0.003)|