Author + information
- Orazberdiyev Yazmuhammet Basimovich1
Depressive disorders of an mild and medium degree of severity at cardiological patients at present are one of actual problems of modern medicine. It became possible in spite of the fact that last years there was a lot of the new highly effective antidepressants which are not possessing unlike to classical tricyclic antidepressant, the expressed behavioural toxicity and negative influence on activity of cardiovascular system. Besides medicamentous therapy in the literature there are reports on efficiency of herbal therapy as antidepressants (Wonnemann M. And co-authors., 2000). One of the most effective in a therapeutic practice of plants is common St. John’s wort, (Hypericum perforatum).
The purpose of research. To study comparative efficiency of some antidepressants from group of selective inhibitors of recapture of the serotonin (SIRS) and an extract of St. John’s wort, (Hypericum perforatum) in treatment of depressive disorders at arterial hypertension (AH) patients with (AH) with the hypertensive encephalopathy (HE).
Results of research. The comparative analysis of results has shown, that in all groups of treatment by 3 month as a whole at 86,6% of patients are reached special-purpose values the of AH and stabilization of clinical course of HE (p<0,001), 68,3% of patients have returned to a former level of psychosocial functioning (p<0,001). Improvement of a psychological condition was shown in reduction of emotional lability, anxiety, phobia, depression, sleep disturbance, improvement of mood and efficiency. The retrospective analysis of results of treatment has shown, that each of used SIRS had some features of psychotropic action.
At prescription to patients with AH with HE of 15 gr/daily an extract of St. John’s wort, (Hypericum perforatum) if the initial score with depressive disorders on scale Beck made 22,6±1,2 in the subsequent it is statistically certainly (p<0,05) has decreased up to 13,8±1,1 points. In 2 months from the beginning of reception of an extract of St. John’s wort, (Hypericum perforatum) at AH patients with psychological disorders, decrease of depression was marked on 35% from initial. Efficiency of therapy with an extract of St. John’s wort, (Hypericum perforatum) to the end of third months of supervision has averaged 55% (p<0,05).
On the basis of the received results it has been proved, that at AH patients with HE for correction of depressive disorders is necessary the differentiated setting of antidepressants from group of selective inhibitors of recapture of serotonin. Application of an extract of St. John’s wort, (Hypericum perforatum) in a dose of 15 gr/daily show the positive antidepressive effect, but this effect on anxiously- phobic disorders was insufficiently.