Author + information
Bartunek J, Behfar A, Dolatabadi D, Vanderheyden M, Ostojic M, Dens J, El Nakadi B, Banovic M, Beleslin B, Vrolix M, Legrand V, Vrints C, Vanoverschelde JL, Crespo-Diaz R, Homsy C, Tendera M, Waldman S, Wijns W, Terzic A. Cardiopoietic Stem Cell Therapy in Heart Failure: The C-CURE (Cardiopoietic stem Cell therapy in heart failURE) Multicenter Randomized Trial With Lineage-Specified Biologics. J Am Coll Cardiol 2013;61:2329–38.
There was an imprecision in the text (page 2330) where 48 patients who entered the consent process are described as ‘randomized’. It would have been more precise to state, “Consent was requested from 48 patients, and 47 were randomized…”.
We here include an updated demographics Table 1 with baseline characteristics pertinent to both analysis as intention to treat and with all patients not receiving cells as controls. Neither the 15/21 nor the 24/21 baseline comparisons reveal significant differences in populations, nor change the outcome of efficacy signals. The revised table corrects for original typographical errors, which had no material impact on trial findings, interpretations or conclusions An updated Table 1 also provides an additional breakdown of control patients. The table also corrects for 2 elements: one related to statistical misprogramming of the SAS data, and a typographical mistake whereby patients under Statins should be 23 (96%) instead of 13 (96%).
A typographical error was noted in Table 2 where the number of patients in the treatment group (Post Cell Rx) of 6 is given a percentage of 20 which should read 28. There are also three rounding errors with 2 of 24 patients (8.33%) rounded to 8.4%, 2 of 24 patients (12.5%) given as (12.6%) and 2 of 21 patients (9.52%) rounded to 9.6%.
In Figure 5C and the Online Appendix, mortality and hospitalization data are at 2 years as described in the Methods. This should have been made clear in respective legends to be consistent with main text (page 2334). Values are accurate in the paper's figures and in main text.
- American College of Cardiology Foundation