Author + information
- Received January 9, 2013
- Accepted January 29, 2013
- Published online August 20, 2013.
- Shireen Brewster, MB, BS⁎,†,
- Bernard Zinman, MD⁎,†,‡,
- Ravi Retnakaran, MSc, MD⁎,†,‡ and
- John S. Floras, MD, DPhil⁎,⁎ ()
Reprint requests and correspondence:
Dr. John S. Floras, Department of Medicine, University of Toronto, Mount Sinai Hospital, 600 University Avenue, Suite 1614, Toronto, Ontario M5G 1X5, Canada
The development of gestational diabetes and even milder forms of dysglycemia during pregnancy represents a maternal phenotype at increased subsequent risk for developing type 2 diabetes mellitus, metabolic syndrome, and, with time, overt cardiovascular disease. A careful and systematic dissection of the hormonal, metabolic, and vascular changes occurring in such women during pregnancy and over the postpartum years provides a unique opportunity to identify conventional and novel conditions and biomarkers whose modification may attenuate adverse long-term outcomes, particularly cardiovascular risk. The purpose of this review is to summarize current understanding of the magnitude of such risk and its potential causes, with a particular focus on postpartum alterations in endothelial and vascular smooth muscle responsiveness.
This work was funded by Operating Grants MOP 84206 from the Canadian Institutes of Health Research and NA 6747 from the Heart and Stroke Foundation of Ontario and a philanthropic donation in memory of Bram and Bluma Appel.
Dr. Brewster was supported by a Mount Sinai Hospital Department of Medicine Post-Doctoral Fellowship. Dr. Floras holds the Canada Research Chair in Integrative Cardiovascular Biology. Dr. Zinman holds the Sam and Judy Pencer Family Chair in Diabetes Research at Mount Sinai Hospital and the University of Toronto. Dr. Retnakaran holds an Ontario Ministry of Research and Innovation Early Researcher Award; and has received grant support from and is a consultant for Merck & Company and Novo Nordisk. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
- Received January 9, 2013.
- Accepted January 29, 2013.
- American College of Cardiology Foundation