Journal of the American College of Cardiology
Clinical Trials
Diagnostic Performance of Noninvasive Fractional Flow Reserve Derived From Coronary Computed Tomography Angiography in Suspected Coronary Artery DiseaseThe NXT Trial (Analysis of Coronary Blood Flow Using CT Angiography: Next Steps)
Bjarne L. Nørgaard, Jonathon Leipsic, Sara Gaur, Sujith Seneviratne, Brian S. Ko, Hiroshi Ito, Jesper M. Jensen, Laura Mauri, Bernard De Bruyne, Hiram Bezerra, Kazuhiro Osawa, Mohamed Marwan, Christoph Naber, Andrejs Erglis, Seung-Jung Park, Evald H. Christiansen, Anne Kaltoft, Jens F. Lassen, Hans Erik Bøtker, Stephan Achenbach and on behalf of the NXT Trial Study Group
Table 5
Table 5
Per-Patient Diagnostic Performance of FFRCT in Patients With Intermediate Stenosis Severity (30% to 70%) According to Coronary CTA
| FFRCT ≤0.80 | Coronary CTA Stenosis >50% | p Value | |
|---|---|---|---|
| Accuracy | 80 (75–85) | 51 (44–57) | <0.0001 |
| Sensitivity | 85 (74–91) | 93 (85–97) | 0.058 |
| Specificity | 79 (72–84) | 32 (26–40) | <0.0001 |
| PPV | 63 (53–72) | 37 (31–44) | <0.0001 |
| NPV | 92 (87–96) | 91 (81–96) | 0.42 |
Values are proportion in % (95% confidence interval). FFR ≤0.80 was diagnostic of ischemia. N = 235.
Abbreviations as in Tables 2 through 4.
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