Author + information
- Hyo-Suk Ahn,
- Hui Kyung Jeon,
- Gee-Hee Kim,
- Woo-Baek Chung,
- Jung Sun Cho,
- Mi-Jeong Kim,
- Eun Joo Cho,
- Hae-Ok Jung and
- Ho-Joong Youn
Long-term therapy with doxorubicin is associated with a high incidence of a cumulative and irreversible dilated cardiomyopathy, despite of its broad anti-neoplastic effectiveness. The goal of this study was to evaluate the cardioprotective effects and safety of seapolyphenol (polyphenol purified from Ecklonia cava) against doxorubicin-induced cardiotoxicity in an animal rat model.
Methods and Results
In total 27 rats including doxorubicin and control groups, baseline and 6 weeks follow up echocardiography were practiced. Relative wall thickness, fractional shortening, and left ventricular ejection fraction significantly decreased and the left ventricular end diastolic/systolic dimension significantly increased in single doxorubicin group and low-dose seapolynol plus doxorubicin group. However, there were no interval changes in high-dose seapolynol plus doxorubicin group. Also, electron microscopic finding showed less impaired myofiber and mitochondria in high-dose seapolynol plus doxorubicin group than in single doxorubicin group (Figure).
Our data showed that high-dose seapolynol had cardioprotective effects against doxorubicin-induced cardiotoxicity in an animal rat model with the evidence of electron microscopic finding in addition to echocardiographic results.
Sunday, March 30, 2014, 3:45 p.m.-4:30 p.m.
Session Title: Heart Failure and Cardiomyopathies: Therapy IV
Abstract Category: 14. Heart Failure and Cardiomyopathies: Therapy
Presentation Number: 1220-161
- 2014 American College of Cardiology Foundation