|Events||Hazard Ratio∗||95% CI||p Value||Events||Hazard Ratio†||95% CI||p Value||Events||Hazard Ratio‡||95% CI||p Value|
|Per 0.1% increase in ectopic beats§||NA||NA||1.08||1.01–1.15||0.020||NA||1.05||1.02–1.07||0.039||NA||0.99||0.93–1.05||0.70|
|<0.1 % ectopic beats||160||8||1.00 = ref||NA||NA||15||1.00 = ref||NA||NA||4||1.00 = ref||NA||NA|
|<85 total APCs or PVCs|
|0.1%–1.5% ectopic beats||321||51||3.13||1.40–7.02||0.005||60||1.84||1.04–3.28||0.037||13||1.00||0.32–3.15||0.99|
|85–1,347 total APCs or PVCs|
|>1.5% ectopic beats||320||49||2.38||1.04–5.42||0.039||89||2.74||1.56–4.82||0.001||16||0.82||0.25–2.65||0.74|
|>1,347 total APCs or PVCs|
|Separate analysis of APCs and PVCs|
|Per 0.1% increase in APCs§||NA||NA||1.01||0.84–1.21||0.96||NA||1.01||0.98–1.05||0.46||NA||0.98||0.91–1.07||0.69|
|Per 0.1% increase in PVCs§||NA||NA||1.08||1.02–1.15||0.016||NA||1.05||1.02–1.07||<0.001||NA||1.00||0.95–1.06||0.94|
VTA = ventricular tachyarrhythmias; other abbreviations as in Table 2.
↵∗ Adjusted for female sex, ischemic cardiomyopathy, left bundle branch block (LBBB), worst New York Heart Association (NYHA) functional class = III, left ventricular ejection fraction (LVEF), and creatinine level.
↵† Adjusted for female sex, ischemic cardiomyopathy, LBBB, prior ventricular arrhythmias, LVEF, and non-U.S. enrolling centers.
↵‡ Adjusted for female sex, ischemic cardiomyopathy, LBBB, worst NYHA class III, LVEF, and creatinine level.
↵§ Estimated by use of an ordinal scale in the range from 0% to 1.5% by 0.1% increase, and pooling patients with more than 1.5% ectopy as a linear relation was no more evident for heart failure/death above this cutoff for ectopic beats.