Author + information
- Åsa Tivesten, MD, PhD∗ (, )
- Liesbeth Vandenput, PharmD, PhD,
- Elizabeth Barrett-Connor, MD and
- Claes Ohlsson, MD, PhD
- ↵∗Wallenberg Laboratory for Cardiovascular and Metabolic Research, Sahlgrenska University Hospital, Bruna Stråket 16, S-413 45 Gothenburg, Sweden
Aspects of gender and biological sex are important to address in research, and we thank Dr. Shufelt and colleagues for their letter. Certainly it would have been suitable to address the association between dehydroepiandrosterone (DHEA), its sulfate, and cardiovascular risk in women in the discussion of our paper (1), even if women were not included in the MrOS cohort. The data by Shufelt et al. (2) are interesting and suggest an association between low DHEA-S and cardiovascular risk in women as in men, whereas other studies have suggested a U-shaped association in women (3).
We also thank Dr. Klevay for sharing his hypothesis regarding copper, coronary heart disease, and DHEA, proposing that low DHEA may be a sign of copper deficiency.
- 2015 American College of Cardiology Foundation
- Tivesten A.,
- Vandenput L.,
- Carlzon D.,
- et al.
- Shufelt C.,
- Bretsky P.,
- Almeida C.M.,
- et al.