Myocardial Edema After Ischemia/Reperfusion Is Not Stable and Follows a Bimodal Pattern
Imaging and Histological Tissue Characterization
Rodrigo Fernández-Jiménez, Javier Sánchez-González, Jaume Agüero, Jaime García-Prieto, Gonzalo J. López-Martín, José M. García-Ruiz, Antonio Molina-Iracheta, Xavier Rosselló, Leticia Fernández-Friera, Gonzalo Pizarro, Ana García-Álvarez, Erica Dall'Armellina, Carlos Macaya, Robin P. Choudhury, Valentin Fuster and Borja Ibáñez
Edematous Reaction After Ischemia/Reperfusion Follows a Bimodal Pattern: The Bimodal Edema Phenomenon
The development of myocardial edema is a well known phenomenon occurring after ischemia/reperfusion (myocardial infarction). This edematous reaction was long assumed to be stable for at least 1 week, but the post-ischemia/reperfusion phase was not previously tracked in a comprehensive serial study. In the present study, analysis of advanced cardiac magnetic resonance and histopathology showed that post-ischemia/reperfusion edema is bimodal. An initial wave of edema abruptly appears upon reperfusion and almost completely disappears at 24 h. A deferred wave appears later and increases progressively until day 7. STIR = short-tau inversion recovery.