Author + information
- Fady Y. Marmoush, MD∗ (, )
- Arvind K. Gireesh, MD and
- Luigi Pacifico, DO
- ↵∗Memorial Hospital of Rhode Island, Alpert Medical School of Brown University, 111 Brewster Street, Internal Medicine Department, Pawtucket, Rhode Island 02860
We read with interest the paper by Menting et al. (1) recently published in the Journal, about the outcome of surgical closure of ventricular septal defect (VSD). We offer the following comment.
VSD is the second most common defect in trisomy-21 after complete atrioventricular septal defect. Irving and Chaudhari (2) showed in their study, on the basis of a population registry, that among 821 infants born with Down syndrome, 31% had VSD. The short life expectancy in patients with Down syndrome can be related to other noncardiac causes. Uppal et al. (3) showed that respiratory-related comorbidities and dementia are among the leading causes of mortality in Down syndrome. In our study of interest (1), survival rates were compared with the expected survival rates of an age-matched Dutch population. Information on the prevalence of trisomy-21 in both groups was not provided. Although the cumulative survival rate was only slightly lower than the general Dutch population after excluding early post-operative mortality, comparing the study cohort with a matching group with similar prevalence of trisomy-21 will result in more accurate cumulative survival rates.
Please note: The authors have reported that they have no relationships relevant to the contents of this paper to disclose.
- American College of Cardiology Foundation
- Menting M.E.,
- Cuypers J.A.,
- Opic P.,
- et al.
- Irving C.A.,
- Chaudhari M.P.