Ischemia Revascularization Equipoise: The ISCHEMIA Trial Design
CCTA may not be performed in participants with estimated glomerular filtration rate <60 ml/min. Participants in whom CCTA shows significant left main disease (≥50% stenosis) or no obstructive disease are excluded. CCTA results are otherwise kept blinded. Cath = catheterization; CCTA = coronary computed tomographic angiography; CKD = chronic kidney disease; eGFR = estimated glomerular filtration rate; OMT = optimal medical therapy; SIHD = stable ischemic heart disease.