Author + information
- Faraz Pathan,
- Nicholas D’Elia,
- Mark Nolan,
- Thomas Marwick and
- Kazuaki Negishi
Current normal reference ranges for atrial strain are based on limited studies of modest size (n=100-350). We sought to update normal ranges for atrial strain.
We searched PubMed, Embase and Scopus databases for key terms: “Left atrial” and “Strain or deformation” and “Speckle tracking or Velocity vector imaging”. Studies reporting global left atrial strain were selected if they involved >50 healthy subjects. Normal ranges for reservoir strain (εR), conduit strain (εCD) and pump strain (εP) were computed using a random-effects model. Meta-regression and subgroup analyses were performed to explore between-study heterogeneity.
Nineteen studies (1789 healthy subjects) satisfied inclusion criteria. Meta-analysis revealed the normal reference ranges were; εR 40±8% (95% CI [37-42]; n=19), εCD 27±8% ([22-32]; 7) and εP 15±6% ([10-21]; 9). The I2 statistic of 98% for εR reflected marked heterogeneity, which was partly explained by E/e’ and body mass index differences in meta-regression (Figure). Subgroup analyses revealed heterogeneity attributable to proportion of women (females <60% vs ≥ 60%: εR 43±8% vs 36±7%, p=0.001) and sample size (≥ 100 and < 100: 44±10% vs 38±7%, p=0.009). Timing of strain triggers, views or vendors showed no significant influence on εR
The normal ranges for εR, εCD and εP are 40±8%, 27±8% and 15±6% respectively. The between-study heterogeneity is partly explained by the gender distribution, sample size, E/e’ and body size.
Moderated Poster Contributions
Non Invasive Imaging Moderated Poster Theater, Poster Area, South Hall A1
Monday, April 04, 2016, 12:45 p.m.-12:55 p.m.
Session Title: Atrial and Ventricular Strain: Diagnostic and Prognostic Roles
Abstract Category: 29. Non Invasive Imaging: Echo
Presentation Number: 1290M-03
- 2016 American College of Cardiology Foundation