Author + information
- Avi Sabbag,
- Anat Berkovitch,
- Yechezkel Sidi,
- Shaye Kivity,
- Roy Binart,
- Shlomo Segev,
- Michael Glikson,
- Ilan Goldenberg and
- Elad Maor
Autonomic dysfunction is associated with the atrial arrhythmogenesis. The purpose of this study was to investigate the association between heart rate reserve (HRR), and new onset atrial fibrillation (AF) among middle-aged adults.
We investigated 15,729 apparently healthy self-referred men and women who underwent periodic health screening examinations between the years 2000-2015. All subjects were free of AF and had completed maximal exercise stress test according to the Bruce protocol at their first visit.
Mean age of study population was 47.8 ± 10 years and 73% were men. Median HRR was 73 ± 3 bpm. A total of 288 (1.81%) incident events occurred during 6.5 ± 4 years. Kaplan Meier survival analysis showed that the cumulative probability of AF at 6 years was higher among subjects low HRR (<73 bpm), compared with those with higher HRR values. (Figure). Multivariable Cox regression analysis showed that low HRR was independently associated with increased AF risk (HR 1.92 [1.3-2.8]) after adjacent for multiple confounders, including age, obesity, fitness and diabetes mellitus. Assessment of HRR as a continuous variable in the same model showed that each 5 bpm decrease in HRR was independently associated with a 3% (p<0.001) increased risk for the occurrence of first AF event.
Poor HRR is independently associated with the development of new onset AF. Further studies are warranted to elucidate the relationship between changes in normal autonomic tone and the pathogenesis of AF.
Poster Area, South Hall A1
Sunday, April 03, 2016, 3:45 p.m.-4:30 p.m.
Session Title: Better Diagnosis and Treatment for AF and SVT
Abstract Category: 16. Arrhythmias and Clinical EP: AF/SVT
Presentation Number: 1235-362
- 2016 American College of Cardiology Foundation