Author + information
- Lei Juan1,2,
- Qiong Qiu1,2,
- Shuxian Zhou1,2,
- Woliang Yuan1,2,
- Yangxin Chen1,2,
- Kan Liu3 and
- Jingfeng Wang1,2
- 1Department of Cardiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China
- 2Guangdong Province Key Laboratory of Arrhythmia and Electrophysiology, Guangzhou, 510120, China
- 3Division of Cardiology, Heart and Vascular Center, Department of Medicine, State University of New York, Upstate Medical University Hospital, Syracuse
To test whether women have more favorable response to cardiac resynchronization therapy (CRT) than men do in Chinese population.
One hundred and twenty-one consecutive CRT recipients (60.8 ± 12.0 years old) in Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University were included in this study. Clinical characteristics and echocardiographic parameters were collected at baseline and 6 months after CRT. CRT response was defined as a left ventricular end systolic volume decrease > 15% after 6 months of implantation compared with baseline. The CRT responses were compared between women and men patients.
Of 121 patients, 37 were women (30.6%). There were no statistical significance differences in age, NYHA classification and drug treatment between two groups (P > 0.05). Female patients have better renal function (Creatinine: 90.9±20.2 μmol/L vs 121.9±39.0 μmol/L, P < 0.01) compared with male patients, and were more often had nonischemic cardiomyopathy (86.5% vs 69.0%, P < 0.05) and left bundle branch block (73.0% vs 45.2%, P < 0.01). Female patients had less smoking (0% vs 58.3%, P < 0.01) and alcohol abuse (0% vs 22.6%, P < 0.01). Both female and male patients had significantly improved clinical and echocardiographic parameters after CRT. The rate of response to CRT in women was much higher than that of men (83.8% vs 64.3%, P < 0.05).
Female recipients have more favorable response to CRT than male patients in Chinese heart failure population.