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Patients with idiopathic hypogonadotropic hypogonadism (IHH) is closely associated with increased cardiovascular events. However, the relationship between cardiac autonomic nerve function(CANF) and IHH is still unclear. We aimed to investigate the CANF in the male patients with IHH.
15 male patients with IHH(IHH group) and 15 male normal volunteers(control group) in our hospital were enrolled. The Ewing tests were used to identify CAN. The parameters of Ewing tests were compared between the two groups. The possible association between levels of sex hormones and parameters of Ewing tests were also analyzed.
Testosterone(T), Follicle-Stimulating Hormone (FSH), Luteinizing Hormone(LH) levels of IHH group were significantly lower than those of the control group(P<0.01). The parameters of Ewing tests(Valsalva ratio, E/I ratio, 30:15 test) of IHH group were significantly lower than those of the control group, while the orthostatic hypotension test was higher, but only the difference of Valsalva ratio was significant(1.17±0.19 vs. 1.45±0.22, P=0.003) between groups. Valsalva ratio was positively related with T, FSH and LH by the Pearson correlation analysis(r=0.64, P=0.012, r=0.45, P=0.024 and r=0.52, P=0.02, respectively).
The cardiac autonomic nerve function of IHH male patients was impaired. The sex hormones were associated with decreased cardiac autonomic nerve function in IHH male patients.