Author + information
- Yaodong Li,
- Yutong Ji,
- Xianhui Zhou,
- Qiang Xing,
- Jianghua Zhang,
- Yanmei Lu and
- Baopeng Tang
Ivabradine is an inhibitor of mixed Na+-K+ current that could combine with HCN channels to reduce the transmembrane velocity of funny current (If), heart rate, and cardiac efficiency, and thus be used for the treatment of cardiovascular diseases such as chronic heart failure. As an ion channel blocker, Ivabradine is also a potential antiarrhythmic agent. To explore the effects of Ivabradine on the electrophysiological parameters in a dog model of age-related atrial fibrillation (AF), and investigate the underlying mechanisms.
Aged Beagle dogs underwent rapid atrial pacing for two months to induce age-related AF in this study. The dogs were randomly divided into the Ivabradine group and control group. The effects of Ivabradine on the electrophysiological parameters, including the effective refractory period (ERP) of the pulmonary veins and atrium, duration of AF, and inducing rate of AF, were investigated.
As compared to the control group, the ERPs of the left superior pulmonary vein (139.00±4.18 ms vs 129.00±4.08 ms, P=0.005) and left auricle (135.00±3.53 ms vs 122.00±4.47 ms, P=0.001) weresignificantly increased, while the duration of AF (46.60±5.07 s vs 205.40±1.14 s, P=0.001) and inducing rate of AF (25% vs 60%, P=0.001) were significantly decreased.
Ivabradine could effectively reduce the inducing rate of AF, and thus be used as an upstream drug for the prevention of age-related AF.