Author + information
- Wang Yong and
- Lan Huang
Atrial fibrillation (AF) is one of the most common arrhythmia while its “true” risk factors are not fully understood. Previous epidemiological studies had discussed the correlation between subclinical atherosclerosis (SAS) and AF but conclusions were inconsistent. We performed this study to quantify the association between SAS and AF.
The electronic databases of Pubmed, Embase, and the Cochrane Library were systematically searched. Cohort and case-control studies that reported relative risk (RR) and 95% CIs for the association between SAS and AF were included. Pooled RRs were calculated using the fixed-effects model.
Total 4 cohort studies and 1 case-control study included 18,059 participants met our inclusion criteria. The highest quartile of intima-media thickness (IMT) was associated with a 72% increased risk of AF (RR=1.72, 95% CI: 1.39- 2.13) compared with the lowest quartile. Presence of carotid plaque could also increase the risk of AF (RR=1.42, 95% CI: 1.17- 1.72) by multivariate analysis.
These findings indicated that SAS was an independent risk factor of AF and it might be a potential therapeutic target in AF prevention.