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To demonstrate the feasibility and effectiveness of a left atrial appendage (LAA) occluder (LAMaxTM plus, Keyidun, China) for the instant occlusion of LAA in canine model, which is specially designed for the occlusion of LAA with two lobes.
Three healthy dogs were used for the implantation of LAMaxTM plus devices, which can be full recapture and repositioning during implantation procedure. Before the implantation, transthoracic echocardiography (TTE) was performed for anatomical evaluation of LAA with two lobes and then transesophageal echocardiography (TEE) followed by angiography. The devices were delivered by 9F or 10F delivery sheathes. The angiography of LAA was performed immediately after the implantation and then TEE examination followed to evaluate the device position, leakage around the device, pericardial effusion, mitral valve function, and pulmonary vein obstruction. The effectiveness of LAA occlusion was assessed by an endpoint of leak around the device less than 3mm of flow by TEE.
The LAMaxTM plus was successfully implanted in all three dogs. By observation of the post-implant TEE, all dogs reached the defined endpoint for the effectiveness of LAA occlusion.
This preliminary study confirms that LAMaxTM plus device is feasible and effective for the instant occlusion of LAA with two lobes in canines. More studies are needed before it can be used in clinical applications.