Author + information
- Tang Kai
Catheter ablation could not eliminate risks of stroke absolutely in patients with atrial fibrillation (AF). Left atrial appendage closure (LAAC) had showed benefits in prevention of stroke in patients with AF. This study was to evaluate the safety and efficacy of combination of LAAC with catheter ablation for the treatment of AF.
Twenty-two patients (M, 13) with persistent AF were enrolled into this study, with a mean age of (78.9±4.7)y. The history of AF was (5.3±3.9)y. All the patients had a history of stroke (from transient ischemia attack to hemiplegy). While transesophageal echocardiography confirmed there were no left atrial thrombus in all the patients 72h before procedure. Circumferential pulmonary vein isolation plus roof line and mitral isthmus line ablation were performed in all the patients. After that, LAAC were performed with Lefort Closer device (Lepu, Beijing, China) in the same procedure. Oral warfarin with aspirin and clopidogrel were taken at 45 days after procedure. Then aspirin and clopidogrel were taken till 6 months. After that, oral aspirin was maintained.
All patients had been performed catheter ablation with LAAC. With a mean duration of (10.9±3.2) months, 15 patients maintained sinus rhythm. No stroke was observed among the patients. There was no case of severe procedure related complications.
This study showed the feasibility and efficacy of combination of LAAC with catheter ablation for the treatment of AF in patients with high risks of stroke.