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Few investigations were concerning the risk factors and predictors of bundle branch blocks (BBBs). C-reactive protein (CRP) has been suggested by previous studies to be a risk factor for cardiovascular diseases. This study aims to investigate possible association between CRP levels and BBBs.
We studied the relationship between high sensitive CRP (hs-CRP) and BBBs among 97,308 participants (mean years 51.78± 12.46, 77623 men) in the Kailuan study. BBBs was assessed by a standard supine resting, 10-s 12-lead ECG, and hs-CRP was measured from blood sample at baseline. The relationship between quartiles of hs-CRP and prevalence of BBBs was analyzed by using logistic regression. The association between quartiles of hs-CRP and the incident BBBs was analyzed by using Cox regression.
After adjusting potential confounders, individuals in higher quartiles of hs-CRP level had a moderate increased likelihood of suffering from BBBs compared using the lowest quartile as the reference. The odd ratios (95% confidence interval) for BBBs of the 2nd, 3rd, 4th quartiles of hs-CRP were 1.13(1.01-1.27), 1.09(0.97-1.33), 1.18(1.05-1.32), respectively, P value for trend was 0.033. BBBs were developed in 1509 individuals during a follow-up of six years. In multivariate analysis with adjustment for potential confounders, the hazard ratios (95% confidence interval) for BBBs of the 2nd, 3rd, 4th quartiles of hs-CRP were 1.10(0.95-1.28), 0.98 (0.84-1.15), 1.21(1.04-1.40), respectively, P value for trend was 0.017.
Higher level of hs-CRP was associated with the higher prevalence of BBBs, and the elevated hs-CRP level was independently related to the increased risk for BBBs. This indicates that the elevated hs-CRP might be a risk marker for BBBs in general population.