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Recent studies have shown that neutrophil-to-lymphocyte ratio(NLR), platelet-to-lymphocyte ratio(PLR) and lymphocyte-to-monocyte ratio(LMR), are new inflammatory markers and predictors for cardiovascular outcomes, being more accurate and stable than absolute blood cell counts. The aim of this study was to investigate whether NLR, PLR and LMR are related to thin-cap fibroatheroma(TCFA) identified by optical coherence tomography(OCT) in patients with coronary artery disease(CAD).
A total of 204 patients (158 with acute coronary syndrome and 46 with stable angina pectoris) who had undergone pre-intervention OCT imaging were enrolled. Patients were divided into a TCFA group (n=81) and a non-TCFA group (n=123). TCFA was defined as a plaque with lipid content in ≥ 2 quadrants and the thinnest part of the fibrous cap measuring < 65 μm. NLR, PLR and LMR, derived from complete blood count(CBC) on admission, were compared between the two groups.
The NLR and PLR levels in the TCFA group were significantly higher than those in the non-TCFA group. (2.43 [IQR,1.77 to 3.77] vs. 1.81 [IQR,1.39 to 2.42]; P=0.000, 131.87 ± 39.46 vs. 113.43 ± 37.74; P=0.001, respectively). The LMR levels in the TCFA group were significantly lower than those in the non-TCFA group. (3.62 [IQR, 2.66 to 4.70] vs. 4.06 [IQR, 3.30 to 5.36]; P=0.004). Moreover, the NLR and LMR were significantly correlated with fibrous cap thickness (r= −0.267, P=0.000 and r= 0.21, P=0.004, respectively).
This study showed that the levels of NLR,PLR and LMR are associated with TCFAs, as detected by OCT. Moreover, NLR and LMR are correlated to fibrous cap thickness.