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To evaluate the clinical application value of myocardial contrast stress echocardiography(MCSE) in detecting myocardial blood flow(MBF).
50 patients hospitalized in the Department of Cardiology, Affiliated Hospital of Jiangsu University were recruited from September 2014 to September 2015. According to the medical history inquiry, physical examination and coronary angiography, all patients were divided into acute myocardial infarction group (n=15), moderate stenosis group (n=9) and control group (n=31). All patients were detected by real-time myocardial contrast echocardiography(MCE), myocardial contrast stress echocardiography(MCSE) and global acoustic densitometry(GAD) before and after dobutamine stress test in order to evaluate the clinical application value of MCSE in detecting MBF. After running GAD software, myocardial visualization peak density (PI) and time to peak density (TP) were calculated, and then MBF[MBF=(PI/TP)oPI] was detected.
After the treatment with dobutamine in control group, PI appeared an increasing trend, TP was reduced and MBF was significantly increased (P < 0.01).
After the treatment with dobutamine in X syndrome group, PI appeared an increasing trend, TP was reduced and MBF was significantly increased. However, there was no significant difference between before and after the treatment (P >0.05).
After the treatment with dobutamine in myocardial infarction, TP was shortened (P < 0.01), MBF was increased (P < 0.05). However, there was no significant change in PI(P > 0.05).
MCE can be used for the examination of myocardial microcirculation integrity and myocardial perfusion. The combination of MCE with MCSE can evaluate non-invasively myocardial contractile function reserves and myocardial perfusion/viability.
Real-time MCE, MCSE and GAD have positive clinical application values in the detection of microcirculation perfusion.
No filling region of myocardial infarction patients in the dobutamine stress test showed sparse filling, which suggests the presence of viable myocardium (VM). The combination of MCE with dobutamine stress test can be widely used in non-invasive assessment of viable myocardium and performs important guiding role in the treatment and prognosis.