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In this study we analyse the effect of per oral administration of the time-released garlic herbal preparation on a rabbit model of in-stent neoatherosclerosis (ISNA) using optical coherence tomography (OCT).
Sirolimus-eluting stents were implanted in the right common carotid arteries of the male New Zealand white rabbits with surgical procedure and then received chow containing 1% cholesterol during the whole animal experiment. Animals were randomly divided into 2 groups (group 1 rabbits were received cholesterol-rich diet with per oral administration of the time-released garlic herbal preparation containing 300 mg garlic powder; group 2 were received just cholesterol-rich diet as control). Stented arterial segments were harvested at 12 weeks after stenting and then processed for optical coherence tomographic analysis and histology. Meanwhile, rabbits were phlebotomized and blood collected for the determination of cytokines levels.
Compared with control subjects, the garlic-treated animals showed lower rate of lipid-rich intima and per-strut low-signal intensity layer, smaller neointimal area and neointimal thickness, larger fibrous cap thickness and minimum lumen area. The serum IL-6, IL-12, MCP-1 and TNF-α decreased and IL-10 increased in the garlic -treated groups.
Garlic prevents the development of cholesterol-induced experimental in-stent neoatherosclerosis compared with control. Targeting of inflammatory pathways after percutaneous coronary intervention may be an efficacious way to prevent restenosis without the long-term risk of late thrombosis.