Author + information
- Huijuan Kou,
- Dengfeng Gao,
- Rui Ma,
- Zhenhua Han and
- Xin Dong
To investigate the relationship between hyperuricemia and renal damage and atherogenic index of plasma (AIP) in patients with primary hypertension.
A total of 231 hypertensive patients were divided into two groups according to the level of uric acid in plasma. Fasting plasma glucose, BUN, Scr, MA, Cys-C, TG, TC, LDL-C, HDL-C and UA and were dynamically monitored by the automatic biochemaical analyzer. The AIP was calculated by the formula (AIP=lgTG/HDL-c). The estimated glomerular filtration rate (eGFR) was calculated by the Cockroff-Gault formula. All the data were analyzed by using the SPSS 13.0 software. For all tests, P<0.05 was considered to be statistically significant.
The hyperuricemia group (n=67) has significantly higher BUN (6.9 v.s. 5.5 mmol/L, P=0.015), Scr (88.9 v.s. 68.7 μmol/L, P<0.001), MA (33.3 v.s. 11.8 mg/L, P<0.001), Cys-C levels (1.26 v.s. 0.97 mg/L, P<0.001) and lower eGFR (65.8 v.s. 84.9 mL/min, P=0.001) level than the control group (n=164). The AIP in hyperuricemia patients was high than the control group, however, no significant differences was observed between the two groups (0.10 v.s. 0.08, P=0.223). The level of blood uric acid was rising with the increase of the quartile of AIP (F=0.976, P=0.405). The level of uric acid in plasma was correlated to the AIP (r=0.144, P=0.032).
The hypertensive patients with hyperuricemia were inclined to suffer from the renal target organ damage. Dynamic observation on the AIP might be helpful to identify the risk of developing atherosclerosis in the hypertensive patients with hyperuricemia.